Research Escalators
HCAR provides facilitated access to research resources and expertise, especially in the areas of research discovery, development and commercialization. Through its relationship with the Penn State Milton S. Hershey Medical Center and the Penn State College of Medicine, research at HCAR is positioned for world-class status.
U.S. News & World Report has cited Penn State Milton S. Hershey Medical Center as one of the best hospitals in the nation, citing several areas of expertise. Penn State College of Medicine is recognized by U.S. News & World Report, March 29, 1999 issue as one of the top medical schools in the country for primary care (which includes the areas of Family Practice, General Internal Medicine and General Pediatrics). This ranking was granted for the second consecutive year.
Areas of expertise include:
Amenities include:
Click below to see the equipment and core facilities that are available onsite at HCAR to resident organizations.
- High-throughput RT-PCR
- Applied Biosystems 7300 Real Time PCR system
- Applied Biosystems 7900 HT Fast Real Time PCR system
- Eppendorf Mastercycler thermocycler
- Eppenorf Thermomixer R
- Laser capture microdissection
- Microlaser Technologies/Zeiss PALM-LCM system/Axiovert microscope
- Bioinformatic analysis
- 2-D gel electrophoresis
- Amersham Ettan IPGphor3 and Ettan DALT12
- Amersham Ettan SpotPicker
- NextGen Biosciences A2DEoptimizer gel caster
- Whole genome gene expression and SNP association
- Axon Instruments GenePix 4000B
- Amersham Bioscience Typhoon 9410 Fluorescence imaging system
- UV/Vis plate readers
- Agilent HP2100 Bioanalyzer
- Nanodrop ND-1000 spectrophotometer
- Molecular Devices Spectromax M2 spectrophotometer
- Illumina Bead Station
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- Super speed and high speed ultracentrifuges
- Beckman J2-MI and Avanti J-E
- Rotors JA-14 (2); JA-17; JA-10
- Beckman L8-M Ultracentrifuge (2)
- Rotors SW-41 (2); SW-50.1 Ti; 75 Ti; 70 Ti; 50 Ti
- Shaking Incubators
- Barnstead Max Q5000 Refrigerated
- Barnstead Max Q5000
- Tabletop Ultracentrifuge
- Beckman Optima MAX with TLA100 rotor Room 3102 (Jong Yun x1508)
- Cold room with FPLC protein purification workstation
- AKTA FPLC system
- 2-D gel electrophoresis
- Amersham Ettan IPGphor II and Ettan DALT12
- Cell culture facilities with hypoxic incubator capability
- Each laboratory maintains their own cell culture facilities.
- Each pod has centralized CO2 delivery systems.
- Hypoxic Incubator
- Gel documentation workstation
- Fuji Intelligent Darkbox II w/ cooled CCD camera
- UVP gel documentation stations (2)
- Kodak film processor
- Barrier Animal Facility
- Liquid scintillation counters (2)
- Beckman LS6000; LS6500
- Fluorescence Microscopy
- fluorescent microscopes
- Nanodrop small volume spectrophotometer ND-1000
- High-end mass spectrometry
- NMR (500-600 MHz)
- Confocal microscopy
- Electron Microscopy
- LC/MS/MS
- Flow cytometry and cell sorting
- Transgenic and KO mouse
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Click below to see the core facilities and shared services available to resident organizations.
- Computer & Sequence Analysis / Bioinformatics - computers, programs, and consultations
- Molecular Genetics/DNA Sequencing and SNPlex analyses
- Organic Synthesis Core
- Macromolecular Synthesis Core (Oligo and Peptide Synthesis (normal, modified, and heavy isotope), protein/peptide Edman Sequencing)
- Microscopy & Histology (Multi-Channel Fluorescence Microscopy, Confocal Microscopy, Spinning Disk Confocal Microscopy, Deconvolution Microscopy, Electron Microscopy)
- Mass Spectrometry (Proteomics: iTRAQ and DIGE gel global quantitation, ID of Co-immunoprecipitated proteins, Post-translational modifications, Peptide MRM validation. Small Molecules: Lipidomics, MRM methods development for small molecule identification and quantification)
- Functional Genomics Core Lab - (Gene Expression Analysis: Microarrays with Affymetrix, Agilent, and Illumina platforms; qRT-PCR and SNP detection: TaqMan platform; Laser-Capture Microdissection, high-throughput robotic sample handling)
- Cell Science & Flow Cytometry Core Lab (FACS analysis and Flow Sorting, six instruments)
- Animals-Transgenic Animal production and breeding, Phenotyping, Re-derivation services, Imaging (Bioluminescent Imaging Services, Micro CT imaging services, MRI & MRS for small animals)
- MRI, MRS, and fMRI imaging of human subjects and animals
- Wyatt Light-Scattering detection for analysis of macromolecule size and aggregation state.
- X-Ray Crystallography Facility
- Solution Phase NMR Facility (500 and 600 Hz instruments with cryoprobe)
- Tissue and Tumor Bank
- Viral Vector Core
- Biostatistics Core
- Cancer Informatics Core (emerging)
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